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Accelerate your research with an upgradable, label-free protein analysis platform | |
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| Octet® R2 protein analysis platform |
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| Octet® R4 protein analysis platform |
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| Octet® R8 protein analysis platform |
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| Inside of R Series |
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| Cat. No. |
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| Octet® R2 System |
견적요청 |
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| Octet® R4 System |
견적요청 |
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| Octet® R8 System |
견적요청 |
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Octet® 은 protein-protein 또는 protein-drug 의 상호반응과 같은 molecular interaction 을 screening 하고 characterization 하는 종합적인 플랫폼입니다. |
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Octet® Biomolecular Interaction Analysis System 은 생체분자 반응을 형광 labeling 없이 실시간으로 분석할 수 있는 시스템으로서
BLI (Bio-Layer Interferometry) 기술을 사용하고 있습니다.
(원리상세보기) |
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바이오의약품 개발과정에서 초기단계부터 최종 생산단계에 이르기까지 진행되는 매우 다양한 applications 에서 사용됩니다.
1. Competition | inhibitor assays
2. DNA | RNA binding proteins
3. Viruses | vaccines
4. Ligand binding
5. Glycans
6. ELISA replacement
7. Manufacturing control bioprocessing QC
8. Small molecules
9. Off-rate ranking
10. FC receptors
11. Aptamers
12. Biosimilars |
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3가지 종류의 Octet® R system
- Octet® R2 system : 2개의 channel 을 이용하여 측정
- Octet® R4 system : 4개의 channel 을 이용하여 측정
- Octet® R8 system : 8개의 channel 을 이용하여 측정
=> 아래 이미지를 참조하세요 |
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Octet® R4 system 은 Octet® R2 system 보다 약 2배 빠르게 샘플을 측정합니다. |
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Octet® R8 system 은 Octet® R4 system 보다 약 2배 빠르게 샘플을 측정합니다. |
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Octet® R2 system 은 Octet® R4 system 으로 간단하게 upgrade 가능합니다. |
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Octet® R4 system 은 Octet® R8 system 으로 간단하게 upgrade 가능합니다. |
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형광 labeling 없이 생체분자 반응을 측정할 수 있습니다. |
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실시간으로 생체분자 binding interaction 을 측정할 수 있습니다. |
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96 개의 sample 을 5분이내로 분석할 수 있습니다. |
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장비를 이용한 측정이 매우 편리합니다. |
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시료의 전처리 과정없이 시료를 바로 측정이 가능합니다. |
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150 Da 크기의 분자까지 detection 할 수 있을 정도로 매우 정밀합니다. |
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10pM 까지 매우 미세한 Affinity (KD) 도 측정 가능합니다. |
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Octet® R8 system 은 다음과 같은 복잡한 조건을 모두 지원
- cGMP
- GLP (Good Laboratory Practice)
- GDP (Good documentation practice)
- GCP (Good Clinical Practice) |
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Octet® R8 system 은 21 CFR Part 11 조건도 지원 |
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| Octet® R Systems |
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| Octet® R2 with 2 biosensor tips |
Octet® R4 with 4 biosensor tips |
Octet® R8 with 8 biosensor tips |
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| Relative time taken for each assay on the Octet® R systems : R8 < R4 < R2 |
| Octet® R Series Assay Capability |
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| Applications |
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R-Series Benefit |
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| Quantitation assays (ELISA replacement) |
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Get precise, real time results |
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Screening Application
(epitope binning, off-rate ranking) | |
Screen mAbs rapidly - obtain multiple critical attributes for optimal candidate selection |
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Large molecule applications
(e.g., viruses, VLPs, nanoparticles) | |
Study a wide range of molecules with one platform and maximize your investment |
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Antibody characterization, DNA, RNA,
Peptides, Protein analytes | |
Easily characterize a diverse range of biologics |
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| Measuring Weak Binding Affinities | |
Detect low affinity binders often missed by ELISA |
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| Measuring Tight Binding Affinities | |
Measure binders with down to pM affinity |
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| Small Molecule Applications | |
Enjoy high sensitivity - measure molecules down to 150 Da |
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| Target ID/Lead Optimization | |
Early Discovery and Development - made easy with the flexibility of increasing throughput |
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| Pre-clinical Development | |
Measure exact antibody responses after treatment or vaccine regime |
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| Process Development / Monitoring | |
Detect and accurately measure process related critical quality attributes |
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| Quality Control | |
Perform lot release and in-process testing with complete confidence |
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| Octet® R Series Technical Specifications |
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| Common Technical Specifications for All Octet® R Systems |
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| Microplate Compatibility |
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96-well plate |
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| Sample Volume | |
180 - 220 μL/well, non-destructive testing |
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| Molecular Weight Detection | |
>150 Da |
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| On-rate (ka) Range (M-1 s-1) | |
101 - 107 |
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| Off-rate (ka) Range (s-1) | |
10-6 - 10-1 |
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| Affinity (KD) Range | |
1 mM - 10 pM |
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| Temperature Control | |
15 - 40°C in 1°C increments |
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| Data Collection Rate | |
2, 5 or 10 Hz |
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| Orbital Flow Capacity | |
Static or 100 - 1500 rpm |
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| Specific Technical Specifications for Each Octet® R System |
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Octet® R2 |
Octet® R4 |
Octet® R8 |
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| Number of Spectrometers |
2 |
4 |
8 |
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| Maximum Simultaneous Reads |
2 |
4 |
8 |
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| Evaporation Cover |
No |
No |
Yes |
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| GxP Compatibility |
No |
No |
Yes |
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| Upgradeability |
To 4 and 8 channels |
To 8 channels |
No |
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| Ordering Information and Related Products |
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| Part Number |
UOM |
Description |
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| Octet® R2 / 30-0512 |
System |
Includes Octet® R2 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty |
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| 41-0327 |
Kit |
Octet® R2 installation and Operational Qualification Kit |
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| Octet® R4 / 30-0514 |
System |
Includes Octet® R4 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty |
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| 41-0326 |
Kit |
Octet® R4 installation and Operational Qualification Kit |
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| Octet® R8 / 30-0518 |
System |
Includes Octet® R8 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty |
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Octet® R8-GxP Package /
30-0518-GxP |
System |
Includes Octet® R8 instrument, 21 CFR Part II software, desktop computer, LCD monitor, accessory kit, IQ/OQ/PQ kits and services, and one-year warranty |
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| 41-0325 |
Kit |
Octet® R8 installation and Operational Qualification Kit |
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| 18-5132 |
Pack |
Single-use evaporation covers to extend the experiment up to 12 hours. Three covers per pack |
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| 18-1176 |
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Octet® R8 Performance Qualification - Quantitation Ki |
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| 18-1177 |
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Octet® R8 Performance Qualification - Kinetics Kit |
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| 18-1178 |
Kits Bundle |
Octet® R8 Performance Qualification Kits Bundle |
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| 50-0296 |
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Software Validation Packag |
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