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Accelerate your research with an upgradable, label-free protein analysis platform
Octet¢ç R2 protein analysis platform
Octet¢ç R4 protein analysis platform
Octet¢ç R8 protein analysis platform
Inside of R Series
Cat. No.
Octet¢ç R2 System °ßÀû¿äû
Octet¢ç R4 System °ßÀû¿äû
Octet¢ç R8 System °ßÀû¿äû
Octet¢ç R Series ºê·Î½´


Octet¢ç Àº protein-protein ¶Ç´Â protein-drug ÀÇ »óÈ£¹ÝÀÀ°ú °°Àº molecular interaction À» screening Çϰí characterization ÇÏ´Â Á¾ÇÕÀûÀÎ Ç÷§ÆûÀÔ´Ï´Ù.
Octet¢ç Biomolecular Interaction Analysis System Àº »ýüºÐÀÚ ¹ÝÀÀÀ» Çü±¤ labeling ¾øÀÌ ½Ç½Ã°£À¸·Î ºÐ¼®ÇÒ ¼ö ÀÖ´Â ½Ã½ºÅÛÀ¸·Î¼­ BLI (Bio-Layer Interferometry) ±â¼úÀ» »ç¿ëÇϰí ÀÖ½À´Ï´Ù.
(¿ø¸®»ó¼¼º¸±â)
¹ÙÀÌ¿ÀÀǾàǰ °³¹ß°úÁ¤¿¡¼­ Ãʱâ´Ü°èºÎÅÍ ÃÖÁ¾ »ý»ê´Ü°è¿¡ À̸£±â±îÁö ÁøÇàµÇ´Â ¸Å¿ì ´Ù¾çÇÑ applications ¿¡¼­ »ç¿ëµË´Ï´Ù.
1. Competition | inhibitor assays
2. DNA | RNA binding proteins
3. Viruses | vaccines
4. Ligand binding
5. Glycans
6. ELISA replacement
7. Manufacturing control bioprocessing QC
8. Small molecules
9. Off-rate ranking
10. FC receptors
11. Aptamers
12. Biosimilars
3°¡Áö Á¾·ùÀÇ Octet¢ç R system
- Octet¢ç R2 system : 2°³ÀÇ channel À» ÀÌ¿ëÇÏ¿© ÃøÁ¤
- Octet¢ç R4 system : 4°³ÀÇ channel À» ÀÌ¿ëÇÏ¿© ÃøÁ¤
- Octet¢ç R8 system : 8°³ÀÇ channel À» ÀÌ¿ëÇÏ¿© ÃøÁ¤
=> ¾Æ·¡ À̹ÌÁö¸¦ ÂüÁ¶Çϼ¼¿ä
Octet¢ç R4 system Àº Octet¢ç R2 system º¸´Ù ¾à 2¹è ºü¸£°Ô »ùÇÃÀ» ÃøÁ¤ÇÕ´Ï´Ù.
Octet¢ç R8 system Àº Octet¢ç R4 system º¸´Ù ¾à 2¹è ºü¸£°Ô »ùÇÃÀ» ÃøÁ¤ÇÕ´Ï´Ù.
Octet¢ç R2 system Àº Octet¢ç R4 system À¸·Î °£´ÜÇÏ°Ô upgrade °¡´ÉÇÕ´Ï´Ù.
Octet¢ç R4 system Àº Octet¢ç R8 system À¸·Î °£´ÜÇÏ°Ô upgrade °¡´ÉÇÕ´Ï´Ù.
Çü±¤ labeling ¾øÀÌ »ýüºÐÀÚ ¹ÝÀÀÀ» ÃøÁ¤ÇÒ ¼ö ÀÖ½À´Ï´Ù.
½Ç½Ã°£À¸·Î »ýüºÐÀÚ binding interaction À» ÃøÁ¤ÇÒ ¼ö ÀÖ½À´Ï´Ù.
96 °³ÀÇ sample À» 5ºÐÀ̳»·Î ºÐ¼®ÇÒ ¼ö ÀÖ½À´Ï´Ù.
Àåºñ¸¦ ÀÌ¿ëÇÑ ÃøÁ¤ÀÌ ¸Å¿ì Æí¸®ÇÕ´Ï´Ù.
½Ã·áÀÇ Àüó¸® °úÁ¤¾øÀÌ ½Ã·á¸¦ ¹Ù·Î ÃøÁ¤ÀÌ °¡´ÉÇÕ´Ï´Ù.
150 Da Å©±âÀÇ ºÐÀÚ±îÁö detection ÇÒ ¼ö ÀÖÀ» Á¤µµ·Î ¸Å¿ì Á¤¹ÐÇÕ´Ï´Ù.
10pM ±îÁö ¸Å¿ì ¹Ì¼¼ÇÑ Affinity (KD) µµ ÃøÁ¤ °¡´ÉÇÕ´Ï´Ù.
Octet¢ç R8 system Àº ´ÙÀ½°ú °°Àº º¹ÀâÇÑ Á¶°ÇÀ» ¸ðµÎ Áö¿ø
- cGMP
- GLP (Good Laboratory Practice)
- GDP (Good documentation practice)
- GCP (Good Clinical Practice)
Octet¢ç R8 system Àº 21 CFR Part 11 Á¶°Çµµ Áö¿ø



Octet¢ç R Systems
Octet¢ç R2 with 2 biosensor tips Octet¢ç R4 with 4 biosensor tips Octet¢ç R8 with 8 biosensor tips
Relative time taken for each assay on the Octet¢ç R systems : R8 < R4 < R2



Octet¢ç R Series Assay Capability
Applications R-Series Benefit
Quantitation assays (ELISA replacement) Get precise, real time results
Screening Application
(epitope binning, off-rate ranking)
Screen mAbs rapidly - obtain multiple critical attributes for optimal candidate selection
Large molecule applications
(e.g., viruses, VLPs, nanoparticles)
Study a wide range of molecules with one platform and maximize your investment
Antibody characterization, DNA, RNA,
Peptides, Protein analytes
Easily characterize a diverse range of biologics
Measuring Weak Binding Affinities Detect low affinity binders often missed by ELISA
Measuring Tight Binding Affinities Measure binders with down to pM affinity
Small Molecule Applications Enjoy high sensitivity - measure molecules down to 150 Da
Target ID/Lead Optimization Early Discovery and Development - made easy with the flexibility of increasing throughput
Pre-clinical Development Measure exact antibody responses after treatment or vaccine regime
Process Development / Monitoring Detect and accurately measure process related critical quality attributes
Quality Control Perform lot release and in-process testing with complete confidence



Octet¢ç R Series Technical Specifications
Common Technical Specifications for All Octet¢ç R Systems
Microplate Compatibility 96-well plate
Sample Volume 180 - 220 ¥ìL/well, non-destructive testing
Molecular Weight Detection >150 Da
On-rate (ka) Range (M-1 s-1) 101 - 107
Off-rate (ka) Range (s-1) 10-6 - 10-1
Affinity (KD) Range 1 mM - 10 pM
Temperature Control 15 - 40¡ÆC in 1¡ÆC increments
Data Collection Rate 2, 5 or 10 Hz
Orbital Flow Capacity Static or 100 - 1500 rpm
Specific Technical Specifications for Each Octet¢ç R System
Octet¢ç R2 Octet¢ç R4 Octet¢ç R8
Number of Spectrometers 2 4 8
Maximum Simultaneous Reads 2 4 8
Evaporation Cover No No Yes
GxP Compatibility No No Yes
Upgradeability To 4 and 8 channels To 8 channels No



Ordering Information and Related Products
Part Number UOM Description
Octet¢ç R2 / 30-0512 System Includes Octet¢ç R2 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty
41-0327 Kit Octet¢ç R2 installation and Operational Qualification Kit
Octet¢ç R4 / 30-0514 System Includes Octet¢ç R4 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty
41-0326 Kit Octet¢ç R4 installation and Operational Qualification Kit
Octet¢ç R8 / 30-0518 System Includes Octet¢ç R8 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty
Octet¢ç R8-GxP Package /
30-0518-GxP
System Includes Octet¢ç R8 instrument, 21 CFR Part II software, desktop computer, LCD monitor, accessory kit, IQ/OQ/PQ kits and services, and one-year warranty
41-0325 Kit Octet¢ç R8 installation and Operational Qualification Kit
18-5132 Pack Single-use evaporation covers to extend the experiment up to 12 hours. Three covers per pack
18-1176 Kit Octet¢ç R8 Performance Qualification - Quantitation Ki
18-1177 Kit Octet¢ç R8 Performance Qualification - Kinetics Kit
18-1178 Kits Bundle Octet¢ç R8 Performance Qualification Kits Bundle
50-0296 Pack Software Validation Packag






 
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