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Accelerate your research with an upgradable, label-free protein analysis platform | |
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Octet¢ç R2 protein analysis platform |
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Octet¢ç R4 protein analysis platform |
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Octet¢ç R8 protein analysis platform |
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Inside of R Series |
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Octet¢ç Àº protein-protein ¶Ç´Â protein-drug ÀÇ »óÈ£¹ÝÀÀ°ú °°Àº molecular interaction À» screening Çϰí characterization ÇÏ´Â Á¾ÇÕÀûÀÎ Ç÷§ÆûÀÔ´Ï´Ù. |
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Octet¢ç Biomolecular Interaction Analysis System Àº »ýüºÐÀÚ ¹ÝÀÀÀ» Çü±¤ labeling ¾øÀÌ ½Ç½Ã°£À¸·Î ºÐ¼®ÇÒ ¼ö ÀÖ´Â ½Ã½ºÅÛÀ¸·Î¼
BLI (Bio-Layer Interferometry) ±â¼úÀ» »ç¿ëÇϰí ÀÖ½À´Ï´Ù. (¿ø¸®»ó¼¼º¸±â) |
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¹ÙÀÌ¿ÀÀǾàǰ °³¹ß°úÁ¤¿¡¼ Ãʱâ´Ü°èºÎÅÍ ÃÖÁ¾ »ý»ê´Ü°è¿¡ À̸£±â±îÁö ÁøÇàµÇ´Â ¸Å¿ì ´Ù¾çÇÑ applications ¿¡¼ »ç¿ëµË´Ï´Ù.
1. Competition | inhibitor assays
2. DNA | RNA binding proteins
3. Viruses | vaccines
4. Ligand binding
5. Glycans
6. ELISA replacement
7. Manufacturing control bioprocessing QC
8. Small molecules
9. Off-rate ranking
10. FC receptors
11. Aptamers
12. Biosimilars |
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3°¡Áö Á¾·ùÀÇ Octet¢ç R system
- Octet¢ç R2 system : 2°³ÀÇ channel À» ÀÌ¿ëÇÏ¿© ÃøÁ¤
- Octet¢ç R4 system : 4°³ÀÇ channel À» ÀÌ¿ëÇÏ¿© ÃøÁ¤
- Octet¢ç R8 system : 8°³ÀÇ channel À» ÀÌ¿ëÇÏ¿© ÃøÁ¤
=> ¾Æ·¡ À̹ÌÁö¸¦ ÂüÁ¶Çϼ¼¿ä |
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Octet¢ç R4 system Àº Octet¢ç R2 system º¸´Ù ¾à 2¹è ºü¸£°Ô »ùÇÃÀ» ÃøÁ¤ÇÕ´Ï´Ù. |
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Octet¢ç R8 system Àº Octet¢ç R4 system º¸´Ù ¾à 2¹è ºü¸£°Ô »ùÇÃÀ» ÃøÁ¤ÇÕ´Ï´Ù. |
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Octet¢ç R2 system Àº Octet¢ç R4 system À¸·Î °£´ÜÇÏ°Ô upgrade °¡´ÉÇÕ´Ï´Ù. |
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Octet¢ç R4 system Àº Octet¢ç R8 system À¸·Î °£´ÜÇÏ°Ô upgrade °¡´ÉÇÕ´Ï´Ù. |
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Çü±¤ labeling ¾øÀÌ »ýüºÐÀÚ ¹ÝÀÀÀ» ÃøÁ¤ÇÒ ¼ö ÀÖ½À´Ï´Ù. |
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½Ç½Ã°£À¸·Î »ýüºÐÀÚ binding interaction À» ÃøÁ¤ÇÒ ¼ö ÀÖ½À´Ï´Ù. |
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96 °³ÀÇ sample À» 5ºÐÀ̳»·Î ºÐ¼®ÇÒ ¼ö ÀÖ½À´Ï´Ù. |
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Àåºñ¸¦ ÀÌ¿ëÇÑ ÃøÁ¤ÀÌ ¸Å¿ì Æí¸®ÇÕ´Ï´Ù. |
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½Ã·áÀÇ Àüó¸® °úÁ¤¾øÀÌ ½Ã·á¸¦ ¹Ù·Î ÃøÁ¤ÀÌ °¡´ÉÇÕ´Ï´Ù. |
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150 Da Å©±âÀÇ ºÐÀÚ±îÁö detection ÇÒ ¼ö ÀÖÀ» Á¤µµ·Î ¸Å¿ì Á¤¹ÐÇÕ´Ï´Ù. |
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10pM ±îÁö ¸Å¿ì ¹Ì¼¼ÇÑ Affinity (KD) µµ ÃøÁ¤ °¡´ÉÇÕ´Ï´Ù. |
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Octet¢ç R8 system Àº ´ÙÀ½°ú °°Àº º¹ÀâÇÑ Á¶°ÇÀ» ¸ðµÎ Áö¿ø
- cGMP
- GLP (Good Laboratory Practice)
- GDP (Good documentation practice)
- GCP (Good Clinical Practice) |
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Octet¢ç R8 system Àº 21 CFR Part 11 Á¶°Çµµ Áö¿ø |
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Octet¢ç R Systems |
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Octet¢ç R2 with 2 biosensor tips |
Octet¢ç R4 with 4 biosensor tips |
Octet¢ç R8 with 8 biosensor tips |
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Relative time taken for each assay on the Octet¢ç R systems : R8 < R4 < R2 |
Octet¢ç R Series Assay Capability |
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Applications |
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R-Series Benefit |
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Quantitation assays (ELISA replacement) |
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Get precise, real time results |
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Screening Application (epitope binning, off-rate ranking) | |
Screen mAbs rapidly - obtain multiple critical attributes for optimal candidate selection |
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Large molecule applications (e.g., viruses, VLPs, nanoparticles) | |
Study a wide range of molecules with one platform and maximize your investment |
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Antibody characterization, DNA, RNA, Peptides, Protein analytes | |
Easily characterize a diverse range of biologics |
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Measuring Weak Binding Affinities | |
Detect low affinity binders often missed by ELISA |
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Measuring Tight Binding Affinities | |
Measure binders with down to pM affinity |
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Small Molecule Applications | |
Enjoy high sensitivity - measure molecules down to 150 Da |
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Target ID/Lead Optimization | |
Early Discovery and Development - made easy with the flexibility of increasing throughput |
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Pre-clinical Development | |
Measure exact antibody responses after treatment or vaccine regime |
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Process Development / Monitoring | |
Detect and accurately measure process related critical quality attributes |
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Quality Control | |
Perform lot release and in-process testing with complete confidence |
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Octet¢ç R Series Technical Specifications |
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Common Technical Specifications for All Octet¢ç R Systems |
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Microplate Compatibility |
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96-well plate |
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Sample Volume | |
180 - 220 ¥ìL/well, non-destructive testing |
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Molecular Weight Detection | |
>150 Da |
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On-rate (ka) Range (M-1 s-1) | |
101 - 107 |
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Off-rate (ka) Range (s-1) | |
10-6 - 10-1 |
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Affinity (KD) Range | |
1 mM - 10 pM |
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Temperature Control | |
15 - 40¡ÆC in 1¡ÆC increments |
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Data Collection Rate | |
2, 5 or 10 Hz |
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Orbital Flow Capacity | |
Static or 100 - 1500 rpm |
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Specific Technical Specifications for Each Octet¢ç R System |
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Octet¢ç R2 |
Octet¢ç R4 |
Octet¢ç R8 |
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Number of Spectrometers |
2 |
4 |
8 |
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Maximum Simultaneous Reads |
2 |
4 |
8 |
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Evaporation Cover |
No |
No |
Yes |
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GxP Compatibility |
No |
No |
Yes |
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Upgradeability |
To 4 and 8 channels |
To 8 channels |
No |
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Ordering Information and Related Products |
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Part Number |
UOM |
Description |
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Octet¢ç R2 / 30-0512 |
System |
Includes Octet¢ç R2 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty |
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41-0327 |
Kit |
Octet¢ç R2 installation and Operational Qualification Kit |
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Octet¢ç R4 / 30-0514 |
System |
Includes Octet¢ç R4 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty |
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41-0326 |
Kit |
Octet¢ç R4 installation and Operational Qualification Kit |
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Octet¢ç R8 / 30-0518 |
System |
Includes Octet¢ç R8 instrument, desktop computer, LCD monitor, accessory kit and one-year warranty |
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Octet¢ç R8-GxP Package / 30-0518-GxP |
System |
Includes Octet¢ç R8 instrument, 21 CFR Part II software, desktop computer, LCD monitor, accessory kit, IQ/OQ/PQ kits and services, and one-year warranty |
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41-0325 |
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Octet¢ç R8 installation and Operational Qualification Kit |
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18-5132 |
Pack |
Single-use evaporation covers to extend the experiment up to 12 hours. Three covers per pack |
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18-1176 |
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Octet¢ç R8 Performance Qualification - Quantitation Ki |
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18-1177 |
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Octet¢ç R8 Performance Qualification - Kinetics Kit |
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18-1178 |
Kits Bundle |
Octet¢ç R8 Performance Qualification Kits Bundle |
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50-0296 |
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Software Validation Packag |
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