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¿µÁøÄÚÆÛ·¹ÀÌ¼Ç Á¾ÇÕÄ«´Ù·Î±×



Ambr¢ç 250 High Throughput Microbioreactor
Single-use Microbioreactor for Ambr¢ç 250 High Throughput
Single-use Microbioreactor for Ambr¢ç 250 High Throughput
Cat. No.
Ambr¢ç 250 High Throughput Microbioreactor °ßÀû¿äû
ÀÚ¼¼ÇÑ ¼³¸í°ú Á¦Ç°»ç¾çÀº Ä«´Ù·Î±×¸¦ ÂüÁ¶ÇϽʽÿä.
Ambr¢ç 250 High Throughput Microbioreactor Ä«´Ù·Î±× [¿µ¹®]


¼¼Æ÷¹è¾ç °øÁ¤ÀÇ Process Optimization °ú Process Characterization ¿¡ »ç¿ë
12°³ ¶Ç´Â 24°³ÀÇ 100 - 250ml ÀÏȸ¿ë vessel À» ÀÌ¿ëÇÏ¿© ¼Ò·®À¸·Î ¸¹Àº °³¼öÀÇ ¼¼Æ÷¹è¾çÀ» ÁøÇàÇÏ´Â ½Ã½ºÅÛ
ÀüÀÚµ¿À¸·Î ÀÛµ¿ÇÏ´Â Liquid Handling Platform À» ±â¹ÝÀ¸·Î ÇÏ¿© ¼¼Æ÷¹è¾ç¿¡ ÇÊ¿äÇÑ liquid ¸¦ media ¿¡ °ø±Þ
µ¿¹°¼¼Æ÷ ¶Ç´Â ¹Ì»ý¹°¼¼Æ÷ÀÇ ¹è¾ç¿¡ »ç¿ë
¼¼Æ÷ÁÖ (strain) screening, °¡Àå È¿À²ÀûÀÎ ¼¼Æ÷¹è¾ç Á¶°Ç È®ÀÎ µîÀÇ ¸ñÀûÀ» À§ÇØ ¼¼Æ÷¹è¾çÀ» ¼Ò·®À¸·Î ÁøÇàÇÏ´Â small-scale cell culture system
ÀÌ ½Ã½ºÅÛÀ» ÅëÇØ È®¸³µÈ ¼¼Æ÷ÁÖ ¶Ç´Â ¼¼Æ÷¹è¾ç Á¶°Ç µîÀ» ¹ÙÅÁÀ¸·Î bench-top ¶Ç´Â larger tank bioreactor ¿¡¼­ ¼¼Æ÷ ¹è¾çÀ» ÁøÇà
Ambr¢ç 250 High Throughput ½Ã½ºÅÛÀ» ÀÌ¿ëÇϸé 12°³ ¶Ç´Â 24°³ÀÇ ¼¼Æ÷¹è¾çÀ» µ¿½Ã¿¡ ÁøÇàÇϹǷΠ¼¼Æ÷¹è¾ç »ý»ê¼ºÀÌ ¸Å¿ì ³ô´Ù.
DoE (Design of Experiment, ½ÃÇè¼³°è) ½ÇÇè¿¡ ÀûÇÕ
ƯÁ¤ÀÇ clone °ú strain À» À§ÇÑ °øÁ¤ °³¹ß¿¡ À¯¿ëÇÑ Tool
ÀÌ ½Ã½ºÅÛ¿¡ »ç¿ëµÇ´Â 100 - 250ml ÀÏȸ¿ë vessel Àº À̺¸´Ù Å« SARTORIUS vessel °ú ±âº» ±¸Á¶°¡ µ¿ÀÏÇϹǷΠ´ë·®ÀÇ cell culture °¡ ½±°Ô ÀÌ·ç¾îÁø´Ù
¸ðµç °úÁ¤ÀÌ ÀÚµ¿À¸·Î ÀÌ·ç¾îÁö°í ¸ðµç ¼¾¼­µéÀÌ ÀåÂøµÇ¾îÁø ÀÏȸ¿ë bioreactor ¸¦ ÀÌ¿ëÇϹǷΠ½ÇÇè°úÁ¤ÀÌ ¸Å¿ì Æí¸®
bioreactor ´ç 3°³ÀÇ gas °ø±Þ
- µ¿¹°¼¼Æ÷¹è¾ç¿¡´Â O2, CO2, N2 | Air °ø±Þ
- ¹Ì»ý¹° ¹è¾ç¿¡´Â O2, Air, N2 °ø±Þ
vessel ·Î °ø±ÞµÇ´Â gas ¿¡´Â mass flow sensor °¡ ÀåÂøµÇ¾î gas °¡ °ø±ÞµÇ´Â ¾çÀ» ÃøÁ¤ ¹× Á¶Àý
bioreactor ´ç 4°³ÀÇ °íÁ¤¹Ð positive displacement liquid pump °¡ ÀåÂøµÇ¾î vessel ¿¡ liquid °ø±Þ
°¢ bioreactor ÀÇ ¿Âµµ ¼³Á¤ ¹× Á¶Àý
°¢ bioreactor ¿¡ ÀåÂøµÇ¾î ÀÖ´Â impeller ÀÇ È¸Àü ¼Óµµ¸¦ °³º°·Î Á¶Àý
¹èÃâ°¡½º ºÐ¼®ÀåÄ¡¸¦ ¼±ÅÃÇÏ¸é ´ÙÀ½°ú °°Àº ºÐ¼® °¡´É .
- OUR (oxygen uptake rate) : »ê¼Ò ¼Òºñ ¼Óµµ °è»ê
- CER (Carbon Dioxide Evolution Rate) : ź¼Ò ¹ß»ý ¼Óµµ °è»ê
Pump ¿Í Liquid Line À» CIP & SIP °¡´É



Bioreactor Vessel
[1] Septum Cap
syringe ¸¦ ÀÌ¿ëÇÏ¿© liquid ¸¦ ½Å¼ÓÇÏ°Ô vessel ³»ºÎ·Î ÅõÀÔ °¡´É
 
[2] Gas Tube
gas µéÀº headspace ·Î ÅõÀԵǰųª ¶Ç´Â sparge ¸¦ ÅëÇØ media ·Î Á÷Á¢ ÅõÀԵǸç ÀÌ·¯ÇÑ gas ÅõÀÔ ¹æ½ÄÀº °¢ tube ¿¡ µû¶ó °³º°·Î ÀÛµ¿ÇÏ¸ç µ¶¸³ÀûÀ¸·Î Á¶ÀýµÈ´Ù.
 
[3] Integrated pH and DO Sensor
ÀÏȸ¿ë pH ¼¾¼­¿Í DO ¼¾¼­°¡ ÀåÂøµÇ¾î ½Ã½ºÅÛ Áغñ °úÁ¤ÀÌ ¸Å¿ì Æí¸®
 
[4] Double Impeller - Rushton or Pitch - blade
Rushton impeller ´Â ¹Ì»ý¹°¹è¾ç¿¡, Pitch Blade impeller ´Â ¼¼Æ÷¹è¾ç¿¡ »ç¿ë



Ambr 250¢ç High Throughput Platform

Ambr¢ç 250 High Throughput Platform Àº bioreactor stations, sensor readers, pumps ±×¸®°í liquid handler °¡ ÀåÂøµÇ¾î ÀÖ¾î °øÁ¤ °³¹ß°ú °øÁ¤ÀÇ ÃÖÀûÈ­¿¡ °¡Àå ÀûÇÕÇÑ scale-down model
[1] Automated Liquid Handler : ÀüÀÚµ¿À¸·Î ±¸µ¿µÇ´Â liquid handler ´Â ½Ã½ºÅÛ³»ÀÇ ¸ðµç liquid ÅõÀÔÀ» ÀÚµ¿À¸·Î ÁøÇàÇÏ¿© »ç¿ëÀÚ¿¡ µû¸¥ ¿ÀÂ÷°¡ ¾ø´Ù.
[2] Bioreactor Station Array : 12°³ ¶Ç´Â 24°³ÀÇ bioreactor station ¸ðµÎ °¢°¢ ´Ù¸¥ Á¶°ÇÀ¸·Î ¼¼Æ÷¹è¾çÀÌ °¡´ÉÇÏ¿© DoE (Design of Experiment, ½ÃÇè¼³°è) ½ÇÇèÀ» Æí¸®ÇÏ°Ô ¼³°è ¹× ÁøÇàÀ» ÇÒ ¼ö ÀÖ´Ù.
[3] Integrated Biological Safety Cabinet : bioreactor station °ú liquid handling system ¸ðµÎ class II Biological safety cabinet ¾È¿¡ ÀåÂøµÇ´Â ±¸Á¶·Î µÇ¾î ¸ðµç ¼¼Æ÷¹è¾ç °øÁ¤ÀÌ ¸ê±Õ°ø°£¾È¿¡¼­ ÀÌ·ç¾îÁ® ¿À¿°ÀÇ ¿°·Á°¡ ¾ø´Ù.


Scalability
Single-Use from Cell Line and Process Development to Production







Sartorius Ambr 250 HT Microcarrier Bioreactor



 
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