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¿µÁøÄÚÆÛ·¹ÀÌ¼Ç Á¾ÇÕÄ«´Ù·Î±× |
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Phagocytosis ´Â º´¿øü, Á׾´Â ¼¼Æ÷ ¹× ¿Ü·¡ ¼¼Æ÷¸¦ ü³»¿¡¼ internalization, Æı« ¹× Á¦°ÅÇÏ´Â ¿ªµ¿ÀûÀÌ°í º¹ÀâÇÑ °úÁ¤ÀÔ´Ï´Ù.
ÀÌ´Â Á¾¾çÇÐ, ¸é¿ª Á¾¾çÇÐ, neuro-inflammation µî ¿©·¯ Ä¡·á ºÐ¾ß¿Í ¿¬°üÀÌ µÇ¾î ÀÖ½À´Ï´Ù.
Phagocytosis ´Â ¸é¿ª ¼¼Æ÷ÀÎ macrophages, neutrophils, immature dendritic cells ±×¸®°í and microglia ¿Í °°Àº ¸é¿ª¼¼Æ÷µéÀÌ ÁøÇàÇÏ´Â cellular endocytosis ¿Í °°Àº °úÁ¤ÀÔ´Ï´Ù.
phagocytosis ÀÇ °¡Àå Áß¿äÇÑ ±â´ÉÁß Çϳª´Â apoptosis °úÁ¤¿¡ ÀÖ´Â ¼¼Æ÷µéÀ» Á¦°ÅÇÏ´Â efferocytosis À̸ç ÀÌ´Â inflammatory Çö»óÀ» ÇØ°áÇÏ´Â µ¥ ¸Å¿ì Áß¿äÇÕ´Ï´Ù.
Efferocytosis ´Â ¶ÇÇÑ ¸¸¼º inflammation À¸·ÎÀÇ ÁøÇàÀ» ¹æÁöÇÏ°í ¶ÇÇÑ Ç×¾ÏÁ¦ Ä¡·á ÈÄ apoptotic tumor cells Á¦°Å¿¡µµ °ü¿©ÇÕ´Ï´Ù.
¶ÇÇÑ, »ì¾ÆÀÖ´Â ¼¼Æ÷µµ host phagocytes ¿Í °áÇÕÇÏ¿© engulfment ¿Í clearance ¸¦ ÃËÁøÇÏ´Â pro-phagocytic agents ¿¡ ÀÇÇØ Ç¥ÀûÀÌ µÉ ¼öµµ ÀÖ½À´Ï´Ù.
ÀÌ·¯ÇÑ ±âÀüÀº Á¾Á¾ Ç×ü¸¦ Ãß°¡ÇÏ¿© Á¦°Å¸¦ À¯µµÇÏ´Â ¹æ½Ä, ¿¹¸¦ µé¾î Ç×ü ÀÇÁ¸¼º ¼¼Æ÷ ½ÄÀÛ¿ë(ADCP)À̳ª CD47°ú °°Àº ¡°don¡¯t-eat-me¡± ½ÅÈ£¸¦ Â÷´ÜÇÏ´Â ¹æ½ÄÀ» Æ÷ÇÔÇÕ´Ï´Ù.
Live-cell analysis ´Â pH-sensitive florescent dye ¸¦ ÀÌ¿ëÇÏ¿© target cell ÀÇ efferocytosis ¸¦ Á¤·®È ÇÒ ¼ö ÀÖÀ¸¸ç ÀÌ´Â Àüü fluorescence ÀÇ Áõ°¡ Á¤µµ¿¡ ÀÇÇØ target cell ÀÇ efferocytosis ¸¦ Á¤·®ÈÇÏ°Ô µË´Ï´Ù.
Key webinar discussion topics include :
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Incucyte¢ç Live-Cell Analysis Systems À» ÀÌ¿ëÇÑ Phagocytosis ÀÇ Quantification |
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½ÇÇè Set-up ¹× Optimization, ±×¸®°í Live-Cell Analysis ¸¦ ÀÌ·¯ÇÑ ¿¬±¸ ¶Ç´Â °³¹ßÀÇ °¢ ´Ü°è¿¡ È¿°úÀûÀ¸·Î Àû¿ëÇÏ´Â ¹æ¹ý¿¡ ´ëÇÑ ¾È³» |
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pHrodo¢ç ½Ã¾à°ú Incucyte¢ç Live-Cell Analysis Systems À» ÀÌ¿ëÇÏ¿© phagocytosis ÀÇ À̹ÌÁö ±â¹ÝÀÇ Çü±¤ Æǵ¶°ª¿¡ ´ëÇÑ °ËÁõµÈ ºÐ¼®¹ý ¾È³». |
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immuno-oncology, inflammation & infection ±×¸®°í neuroscience ºÐ¾ß¿¡¼ ½Ç½Ã°£ ¼¼Æ÷ ºÐ¼®ÀÇ È°¿ëÀ» µÞ¹ÞħÇÏ´Â ¿¹½Ã µ¥ÀÌÅÍ.. |
Speaker
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Jasmine Trigg
Associate Scientist
Sartorius |
JasmineÀº ÇöÀç SartoriusÀÇ Bio Analytics ÆÀ ³»ÀÇ cell imaging nd applications ±×·ì¿¡¼ Associate Scientist ·Î ±Ù¹«ÇÏ°í ÀÖ½À´Ï´Ù.
Áö³ ¸î ³â µ¿¾È ±×³à´Â ¿©·¯ ¿¬±¸ ºÐ¾ß¿¡¼ cellular assay ¸¦ °³¹ßÇÏ¿´À¸¸ç À̸¦ È°¿ëÇÏ¿© ½Ç½Ã°£ ¼¼Æ÷ ºÐ¼® ÀÀ¿ë ÇÁ·Î±×·¥ÀÇ ¹üÀ§¸¦ È®ÀåÇÏ´Â ÀÏÀ» ÇØ¿Ô½À´Ï´Ù.
Jasmine ÀÇ background ´Â Neuroscience and Genetic Manipulation À̸ç, Ãʱ⠿¬±¸¿¡¼´Â ±¸Á¶ »ý¹°Çаú ºÐÀÚ »ý¹°ÇÐÀ» °áÇÕÇÑ Á¢±Ù ¹æ½ÄÀ» ÀÌ¿ëÇÏ¿©
¾ËÃ÷ÇÏÀÌ¸Ó º´°ú °ü·ÃµÈ ´Ü¹éÁú¿¡ ÁýÁßÇÏ¿© ¿¬±¸¸¦ ÁøÇà ÇÏ¿´½À´Ï´Ù.
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